Recent Advances on Biomarkers of Sepsis-induced Acute Kidney Injury
نویسندگان
چکیده
SEPSIS is a complex clinical syndrome involving both infection and a deleterious host immune response. Actue Kidney Injury (AKI) is a frequent and serious complication of sepsis in Intensive Care Unitpatient (ICU). Despite recent impressive advances in the pathophysiology, diagnostic procedures, and appropriate therapeutic interventions in sepsis, sepsis-induced AKI fails to reduce the overwhelmingly high mortality rate and longer hospital stay. A major obstacle for effective treatment of sepsis-induced AKI is the relative lack of specific early and effective diagnostic tools. Current clinical Serum Creatinine (Scr) is unable to detect the early AKI, in the past ten decades, studies have identified several biomarkers for the early diagnosis of AKI, but only limited information exists concerning their values in the diagnosis of sepsis-induced AKI. In this article, we have made a comprehensive review to discuss the clinical value of biomarkers in the diagnosis of sepsis-induced AKI.
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